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Post by misspiggy on Feb 15, 2012 0:00:14 GMT 1
Jimmy is forever in my thoughts, little sayings or specific songs. Looking at holiday phot's bring back so many happy memories I had with Jimmy & Deanne. Miss you both so much. Jimmy I hope you're out of pain and I hope Deanne has been able to move on with her life, I know she'll never forget her soul mate xx
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Deanne
Feb 14, 2012 23:56:46 GMT 1
Post by misspiggy on Feb 14, 2012 23:56:46 GMT 1
Just been going through my photo's and they've brought lots of tears and also lots of laughter. Jimmy was such a wonderful man, I miss his wicked ways and his funny laughter, he brightened up the day. He's forever in my thoughts. Miss all those wonderful times we had with Jimmy & Deanne, what a wonderful couple they were. Maria xxxxx
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Post by findmaster on Oct 22, 2011 16:35:29 GMT 1
Dear Web Master, We are in process of link building of our site to increase its relevancy and traffic. Can you give me information on how I can place my link on your page? Our link details are following: Title: Canadian Pharmacy URL: www.canadadrugcenter.com/Description: CanadaDrugCenter.com is America's choice for safe and affordable prescription and non-prescription medications. Our licensed Canadian mail order pharmacy will provide you with substantial savings on all your medication needs.
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caz
New Member
Posts: 25
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Post by caz on Jul 12, 2010 21:07:53 GMT 1
Oh Deanne I am so sad to learn of Jimmy x I have not looked at the forum for a very long time, my thoughts are with you, yes I know what you are going through xxxxxxx caz
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Post by dtay on Feb 5, 2010 18:17:37 GMT 1
Deanne I have logged in today - the first time in ages - and am so shocked to read about Jimmy. Jimmy will always be thought of as an amzing man, truly inspirational - a fighter, someone who never gave up, and who fought the fight for others and not just himself. My thoughts are with you and your family. God Bless Dawn
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Post by stayingpositive on Sept 19, 2009 0:04:27 GMT 1
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Post by stayingpositive on Sept 18, 2009 22:35:59 GMT 1
I also found this I think from Prof. Sikora: If your case goes to the PCT Exception Committee and it is declined – challenge the decision and the authority of its members. Next step if appeal fails: Complain to the Chief Executive of Hospital (copying the Healthcare Commission) Complain to local PCT It is generally accepted that the majority of cancer sufferers who challenge their PCT win. Make cancer charities aware of your challenge – they can be a mine of information. Get in touch with Doctors for Reform, Halliwells Solicitors, Pamela Northcott Fund. Get in touch with the drug manufacturer. Get as much publicity as possible and do not accept what you are given. Some links below: www.pamelanorthcottfund.org.uk/www.reform.co.uk/DfR/DfRHome/tabid/121/Default.aspxwww.halliwells.co.uk/about/probono.cfm
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Post by stayingpositive on Sept 18, 2009 22:25:12 GMT 1
Hi Deanne, I am fighting to get my husband Tarceva as third line treatment at Ealing PCT in London. He is being treated at Charing Cross Hospital in London and was initially turned down we are now appealing and the panel meets in a couple of weeks. Thankfully we have a sympathetic and helpful Oncologist. I would be interested to know if anyone has had any success in getting Tarceva on the NHS in London - I have heard that Chelsea & Westminster PCT is funding it??
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Post by stayingpositive on Sept 18, 2009 22:13:24 GMT 1
This is very interesting too... news.bbc.co.uk/1/hi/health/7629753.stmbreakdown of PCTs over England who fund Tarceva The BBC contacted all Primary Care Trusts in England, Local Health Boards in Wales, and the NHS in Scotland and Northern Ireland. Focusing on five specific drugs not officially approved for use on the NHS, we asked how many applications they had received from patients in the last financial year - and how many had been granted. The drugs in question were, Avastin, for colon and breast cancer, Erbitux, for colon and lung cancer, Nexavar, for renal and liver cancer, Sutent, for renal cancer, and Tarceva, for lung and pancreatic cancer. Access to the drugs was tightest in London, and easiest in the North West of England. However, there were wide variations, even between neighbouring authorities and in some areas no requests for the drugs had been made.
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Post by stayingpositive on Sept 18, 2009 22:10:47 GMT 1
One of Britain's leading cancer specialists, Karol Sikora, told a meeting of politicians and doctors last week that he had a number of private patients who had begun to order drugs from one of the largest internet pharmacies in Canada, CanadaDrugs.com. 'These patients are well informed, and they shop around for the cheapest prices,' he said. 'I had one patient, a very well educated young woman who wanted Tarceva for lung cancer. She couldn't get the drug on the NHS. The price from a Harley Street clinic worked out at around £75 a tablet - but ordering from Canada would bring it down to £35 a tablet.' He told the conference that a younger generation of patients would demand the best treatments, even if the NHS decided they were not affordable. 'We're in a world where an easyJet flight can be booked within minutes. The idea that you can't get a cancer drug that will extend your life because a government body has decreed you can't have it just won't work.' www.canadadrugs.com/search.php?keyword=tarceva&x=11&y=14
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Post by stayingpositive on Sept 18, 2009 21:57:48 GMT 1
Hello, I am currently fighting the Ealing PCT to get my husband funded for Tarceva as third line treatment. Has anyone had ANY success in getting Tarceva from ANY PCTs in London??!! I know that NICE has approved Tarceva finally for use but only as SECOND LINE TREATMENT.
I would be extremely grateful if anyone could post if they have been successful if getting Tarceva from a PCT in London. Many thanks.
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randyw
Junior Member
Just chillin with my friends
Posts: 80
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Post by randyw on Aug 10, 2009 17:02:13 GMT 1
Lung cancer victims to get vital drug Alimta
Aug 6 2009 by Joanne Butcher, Evening Chronicle Add a comment Recommend
LUNG cancer victims are celebrating the approval of a new treatment.
The National Institute for Health and Clinical Excellence (NICE) has today recommended cancer drug Alimta as a first-line treatment for a type of lung cancer.
The chemotherapy drug is now set to be made available for NHS patients as another treatment option to tackle tumours.
It is estimated that it will benefit 120 patients every year in the North East.
But scores of desperately ill people in the region have already been given Alimta since it was approved by a Newcastle-based body in January this year.
The North of England Cancer Drug Approvals Group gave the drug the thumbs-up seven months ahead of today’s national guidance.
Lung cancer is the UK’s biggest cancer killer and the second most common cancer in the UK after breast cancer, accounting for one in 20 of all deaths nationwide.
But Alimta, which is administered via a drip alongside plantinum-based drug, cisplatin, has been shown in clinical trials to extend life beyond one year in patients with non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers in the UK.
It also improves sufferers’ comfort by reducing patients’ hair loss and the need for constant blood transfusions.
And as only one dose is needed every three weeks it requires less trips to hospital than many current treatments on offer.
Alimta, which has previously hit the headlines as a treatment for asbestos cancer Mesothelioma, is currently recommended as second line treatment for NSCLC.
This means patients must have tried and failed with other options before they can be given a course of Alimta.
But NICE is now recommending the chemotherapy drug as initial treatment for Large-Cell Carcinoma and Adenocarcinoma NSCLC patients, two of the most common types of the cancer.
Nick Thatcher, Professor in Medical Oncology at The Christie NHS Foundation Trust said: “This decision is truly significant and is fantastic news for lung cancer patients in the UK and the clinicians who have been campaigning for access.
“NICE should be commended on allowing UK patients to be the first to have funded access to this combination for the first line treatment.”
A spokesperson for the North of England Cancer Drug Approvals Group said: “The North East has a strong track record in approving cancer drugs for use by the region’s patients. We have approved some drugs far in advance of approval by the NICE for example Herceptin for breast cancer, Alimta for asbestos related lung cancer, Tarceva for lung cancer, Sutent for kidney cancer and Temozolomide for brain cancer.
“We welcome NICE’s announcement today to recommend the use of this combination as it supports our decision seven months ago to approve this drug.
“We expected 120 patients each year to benefit.”
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lynda
New Member
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Post by lynda on Jul 26, 2009 14:45:54 GMT 1
I haven't posted for a long time but pop in now and again.I am so very sorry for your sad loss,Deanne.I'm pleased to have met you and Jimmy and my thoughts and prayers are with you and your family. Love Lynda
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randyw
Junior Member
Just chillin with my friends
Posts: 80
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Post by randyw on Jul 22, 2009 13:50:08 GMT 1
I ahve not been here as much as of recently but I just thought to check in and see how things are going.. Deanne, I am so sorry to hear this news about Jimmy. He is the luckiest man to have a wife that fought so hard for him. You have achieved a lot in a short time to help Jimmy and I hope You are doing well..
My deepest thoughts Prayers and Condolences to you and the Family. On behalf of your friends at LCSC also!!
I did post your note in our obituary column also.
If I can help in any way let me know Please? I know how hard this is going to be.
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Post by gpawelski on Jul 19, 2009 1:19:02 GMT 1
As we enter the era of "personalized" medicine, it is time to take a fresh look at how we evaluate treatments for cancer patients. More emphasis is needed matching treatment to the patient. Patients would certainly have a better chance of success had their cancer been chemo-sensitive rather than chemo-resistant, where it is more apparent that chemotherapy improves the survival of patients, and where identifying the most effective chemotherapy would be more likely to improve survival.
Findings presented at the Annual Meeting of the European Society for Clinical Investigation in Uppsala, Sweden and the Annual Meeting of the American Assoication for Cancer Research (AACR) in San Diego, CA concluded that "functional profiling" with cell-based assays is relevant for the study of both "conventional" and "targeted" anti-neoplastic drug agents (anti-tumor and anti-angiogenic activity) in primary cultures of "fresh" human tumors.
Cell-based Assays with "cell-death" endpoints can show disease-specific drug activity, are useful clinical and research tools for "conventional" and "targeted" drugs, and provide unique information complementary to that provided by "molecular" tests. There have been more than 25 peer-reviewed publications showing significant correlations between cell-death assay results and patient response and survival.
Many patients are treated not only with a "targeted" therapy drug like Tarceva, Avastin, or Iressa, but with a combination of chemotherapy drugs. Therefore, existing DNA or RNA sequences or expression of individual proteins often examine only one compenent of a much larger, interactive process. The oncologist might need to administer several chemotherapy drugs at varying doses because tumor cells express survival factors with a wide degree of individual cell variability.
There is a tactic of using biopsied cells to predict which cancer treatments will work best for the patient, by taking pieces of live "fresh" tumor tissue, applying different chemotherapy treatments to it, and examining the results to see which drug or combination of drugs does the best job killing the tumor cells. A cell-based assay test with "functional profiling," using a cell-death endpoint, can help see what treatments will not have the best opportunity of being successful (resistant) and identify drugs that have the best opportunity of being successful (sensitive).
Funtional profiling measures the response of the tumor cells to drug exposure. Following this exposure, they measure both cell metabolism and cell morphology. The integrated effect of the drugs on the whole cell, resulting in a cellular response to the drug, measuring the interaction of the entire genome. No matter which genes are being affected, functional profiling is measuring them through the surrogate of measuring if the cell is alive or dead.
For example, the epidermal growth factor receptor (EGFR) is a protein on the surface of a cell. EGFR-inhibiting drugs certainly do target specific genes, but even knowing what genes the drugs target doesn't tell you the whole story. Both Iressa and Tarceva target EGFR protein-tyrosine kinases. But all the EGFR mutation or amplificaton studies can tell us is whether or not the cells are potentially susceptible to this mechanism of attack. They don't tell you if Iressa is better or worse than Tarceva or other drugs which may target this. There are differences. The drugs have to get inside the cells in order to target anything. So, in different tumors, either Iressa or Tarceva might get in better or worse than the other. And the drugs may also be inactivated at different rates, also contributing to sensitivity versus resistance.
As an example of this testing, researchers have tested how well a pancreatic cancer patient can be treated successfully with a combination of drugs commonly used to fight lung, pancreatic, breast, and colorectal cancers. The pre-test can report prospectively to a physician specifically which chemotherapy agent would benefit a cancer patient. Drug sensitivity profiles differ significantly among cancer patients even when diagnosed with the same cancer.
The funtional profiling technique makes the statistically significant association between prospectively reported test results and patient survival. It can correlate test results that are obtained in the lab and reported to physicians prior to patient treatment, with significantly longer or shorter overall patient survival depending upon whether the drug was found to be effective or ineffective at killing the patient's tumor cells in the laboratory.
This could help solve the problem of knowing which patients can tolerate costly new treatments and their harmful side effects. These "smart" drugs are a really exciting element of cancer medicine, but do not work for everyone, and a pre-test to determine the efficacy of these drugs in a patient could be the first crucial step in personalizing treatment to the individual.
Literature Citation: Weisenthal, L.M. Functional profiling with cell culture-based assays for kinase and anti-angiogenic agents Eur J Clin Invest 37 (suppl. 1):60, 2007 Nagourney, R.A. Functional Profiling of Human Tumors in Primary Culture: A Platform for Drug Discovery and Therapy Selection (AACR: Apr 2008-AB-1546)
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Post by pipfitz on Jul 14, 2009 11:50:35 GMT 1
Deanne, You've all fought a tremendous fight, I lost my husband (a fit non-smoker of 47) to lung cancer 18 months ago and my heart goes out to you and all his family and friends. Take good care of yourself, he's at peace now. Pippa
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duane
New Member
Posts: 44
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Post by duane on Jul 13, 2009 23:21:40 GMT 1
Hi Deanne, I'll be thinking of you tomorrow Take Care Duane xx
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Post by joanne on Jul 12, 2009 9:21:33 GMT 1
I just want to let u know that I'm thinking of u and ur family at this sad time. I never met u or Jimmy, but reading the previous posts I'm sure that he will b sadly missed. RIP Jimmy.
Love and warmest wishes
Jo xxx
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Post by misspiggy on Jul 12, 2009 1:42:09 GMT 1
Deanne I just don't know what to say..... I'm so deeply sorry...Our thoughts are with you, your family and everyone who was close to Jimmy.
So glad I had the priviledge of knowing Jimmy, he'll always be in my heart and I'll always love him as a really close friend..
I keep hearing his laughter, remember all those times he took the mic out of me for being Welsh...all those funny jokes he used to send..our wonderful holidays together...
I'm going to miss him so much but at least I can always say I was lucky enough to have such a wonderful & true friend.
Maria & Gareth xxx
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curly
New Member
Posts: 7
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Post by curly on Jul 11, 2009 9:39:59 GMT 1
Hi Deanne,
I am devastated at your loss and was shocked rigid when I read of Jimmy's passing, he did indeed put up a remarkable fight and highlighted some shortcomings along the way, which perhaps others will learn from. I bumped into him at least three or four times last year and he seemed so cheerful and fit. looked very much his usual self.
I will remember JJ's laughter which was always infectious, and even through his sufferings he managed to achieve so much that others may never even attempt, he certainly "made his mark".
I'm so sorry, sorry too that I will not be able to join you on Tuesday as I will not be in town (I will once again be at the Freeman Hospital) but my thoughts will be with you.
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Post by vanessa on Jul 10, 2009 22:38:10 GMT 1
Dear Deanne so deeply saddened on the loss of Jimmy he will be greatly missed by all who knew him, what a wonderful man i am truly honoured to have been his friend always in our hearts and never forgotten
luv vanessa & mark xxxxx
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Trace
New Member
A little support goes a long way !
Posts: 23
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Post by Trace on Jul 10, 2009 19:55:54 GMT 1
Dearest Deanne,
Words cannot express how truely sorry we are.
Jimmy will always be one of the most kindest, generous and funniest men we have ever met. We are so honoured to have known him, to call him a friend and have him be such a support to us. We have nothing but fantastic funny memories of Jimmy. He will be sadly missed.
Deanne, we send you all our love and deepest sympathy.
Trace & Darren. xxx
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duane
New Member
Posts: 44
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Post by duane on Jul 9, 2009 18:39:37 GMT 1
Hi Deanne, I'm just lost for words, I know I've never met you or Jimmy face to face but I feel I've lost a great friend. Throughout Ange's illness you were both so willing to share your experiences & offer help it became part of my routine to check these boards every day. I'm so sorry for your loss. Sending you lots of love and ((((hugs))))
Duane xx
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jill
New Member
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Post by jill on Jul 9, 2009 17:26:20 GMT 1
So very sorry. I have been following Jimmys progress since my husband was diagnosed in May 2007.. sadly he too died recently, age 53. he never smoked and, like Jimmy, tried so hard to beat the illness so he could stay with me and our 3 children. Love to you and your family.
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Post by Deanne Jenkyns on Jul 9, 2009 16:20:53 GMT 1
My Sweet Darling Man lost his battle on Tuesday 7/07/09 just after 8pm. I was with him, he went peacefully in my arms. How I will ever get through my life without him I just don't know. Jimmy is my hero and he fought so hard. I love him with all my heart I feel so sad but I know he had to go. He was tired bless him. Funeral is on Tuesday as south shields Crematorium at 12:30pm
Night Night my sweet I love you so much. xxxx
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